$Unique_ID{BRK03079} $Pretitle{} $Title{chlordiazepoxide and clidinium combination} $Subject{Clindex Rugby Clinoxide Geneva Generics Clipoxide Schein Librax Roche Lidox Major Benzodiazepine antianxiety anticholinergic Chlordiazepoxide clidinium peptic ulcer irritable bowel syndrome slows gastrointestinal tract stomach acid benzodiazepine tranquilizers depressant central nervous system} $Volume{} $Log{Librax*0307901.scf} Copyright (C) 1993 Publications International, Ltd. chlordiazepoxide and clidinium combination ------------------------------------------------------------------------------ BRAND NAMES (Manufacturers) chlordiazepoxide with clindinium bromide (various manufacturers) Clindex (Rugby) Clinoxide (Geneva Generics) Clipoxide (Schein) Librax (Roche) Lidox (Major) TYPE OF DRUG Benzodiazepine antianxiety and anticholinergic INGREDIENTS Chlordiazepoxide and clidinium DOSAGE FORM Capsules (5 mg chlordiazepoxide and 2.5 mg clidinium) STORAGE Chlordiazepoxide and clidinium combination capsules should be stored at room temperature in a tightly closed, light-resistant container. USES Chlordiazepoxide and clidinium combination is used in conjunction with other drugs to treat peptic ulcer or irritable bowel syndrome. Clidinium is an anticholinergic agent that slows the activity of the gastrointestinal tract and reduces the production of stomach acid. Chlordiazepoxide belongs to a group of drugs known as benzodiazepine tranquilizers. It is not clear exactly how chlordiazepoxide works, but it may relieve anxiety by acting as a depressant of the central nervous system. TREATMENT You should take chlordiazepoxide and clidinium combination 30 to 60 minutes before meals. It can be taken with water or milk. Do not take it with antacids, since they may interfere with its absorption. If you miss a dose of this medication, take the missed dose as soon as possible, unless it is almost time for you to take your next dose. In that case, do not take the missed dose at all; just return to your regular dosing schedule. Do not double the next dose. SIDE EFFECTS Minor. Blurred vision, change in your sense of taste, confusion, constipation, decreased sweating, depression, diarrhea, dizziness, drowsiness, dry mouth, fatigue, headache, insomnia, nausea, or vomiting. These side effects should disappear as your body adjusts to the medication. This medication can cause increased sensitivity to sunlight. You should, therefore, avoid prolonged exposure to sunlight and sunlamps. Wear protective clothing and sunglasses, and use an effective sunscreen. Dry mouth can be relieved by chewing sugarless gum or by sucking on ice chips or a piece of hard candy. To relieve constipation, increase the amount of fiber in your diet (fresh fruits and vegetables, salads, bran, and whole-grain breads), exercise, and drink more water (unless your doctor directs you to do otherwise). To avoid dizziness or light-headedness when you stand, contract and relax the muscles of your legs for a few minutes before rising. Do this by pushing one foot against the floor while raising the other foot slightly, alternating feet so that you are "pumping" your legs in a pedaling motion. Major. Tell your doctor about any side effects that are persistent or particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about decreased sexual ability, difficulty in breathing, difficult or painful urination, excitation, fluid retention, hallucinations, palpitations, rash, sore throat, uncoordinated movements, or yellowing of the eyes or skin. INTERACTIONS This medication interacts with several other types of drugs: 1. Extreme drowsiness can occur when this medicine is taken with other central nervous system depressants (such as alcohol, antihistamines, barbiturates, muscle relaxants, narcotics, pain medications, phenothiazine tranquilizers, and sleeping medications) or with tricyclic antidepressants. 2. Chlordiazepoxide can decrease the effectiveness of carbamazepine, levodopa, and oral anticoagulants (blood thinners) and may increase the effects of phenytoin. 3. Disulfiram, oral contraceptives (birth control pills), isoniazid, and cimetidine can increase the blood levels of chlordiazepoxide, which could possibly lead to toxic effects. 4. Concurrent use of rifampin may decrease the effectiveness of chlordiazepoxide and clidinium. 5. Amantadine, haloperidol, phenothiazine tranquilizers, procainamide, quinidine, and tricyclic antidepressants may increase the side effects of clidinium. Before starting to take this medication, BE SURE TO TELL YOUR DOCTOR about any medications you are currently taking, especially any of those listed above. WARNINGS * Tell your doctor if you have ever had unusual or allergic reactions to any medications, especially to chlordiazepoxide or other benzodiazepine tranquilizers (such as alprazolam, clorazepate, diazepam, flurazepam, halazepam, lorazepam, oxazepam, prazepam, temazepam, and triazolam) or to clidinium. * Tell your doctor if you now have or if you have ever had glaucoma, obstructed bladder or intestine, enlarged prostate gland, heart disease, lung disease, liver disease, kidney disease, ulcerative colitis, porphyria, high blood pressure, myasthenia gravis, epilepsy, thyroid disease, emotional instability, or hiatal hernia. * This medication can decrease sweating and heat release from the body. You should, therefore, avoid becoming overheated by strenuous exercise in hot weather and should avoid taking hot baths, showers, and saunas. * This medicine can cause drowsiness. Avoid tasks that require alertness, such as driving a car or operating potentially dangerous equipment. * Before having surgery or any other medical or dental treatment, tell your doctor or dentist that you are taking this drug. This medication has the potential for abuse and must be used with caution. Tolerance develops quickly; do not increase the dosage unless you first consult your doctor. It is also important not to stop taking this drug suddenly if you have been using it in large amounts or for longer than several weeks. Your doctor may reduce the dosage gradually. * This is a safe drug when used properly. When it is combined with other sedative drugs or alcohol, however, serious side effects may develop. * Be sure to tell your doctor if you are pregnant. This medicine may increase the chance of birth defects if it is taken during the first three months of pregnancy. In addition, too much use of this medicine during the last six months of pregnancy may cause the baby to become dependent on it. This may result in withdrawal symptoms in the infant at birth. Use of this medicine during the last weeks of pregnancy may cause excessive drowsiness, slowed heartbeat, and breathing difficulties in the newborn infant. Also, tell your doctor if you are breast-feeding an infant. This medicine may pass into breast milk and cause excessive drowsiness, slowed heartbeat, and breathing difficulties in the nursing infant. ---------------- The material contained here is "FOR INFORMATION ONLY" and should not replace the counsel and advice of your personal physician. Promptly consulting your doctor is the best path to a quick and successful resolution of any medical problem.