$Unique_ID{BRK02069} $Pretitle{} $Title{Causes, Symptoms, and Treatment of Pyelonephritis} $Subject{pyelonephritis kidney infection renal pelvis ureter urine bladder urination Escherichia coli urethra kidney stones kidney stone enlargement prostate gland scars infections infection pregnancy falling uterus catheterization diabetes chills fever pain nausea vomiting antibiotics} $Volume{} $Log{ Types of Urinary Tract Infections*0007101.scf Predisposing Factors for Urinary Tract Infections*0007102.scf Pyelonephritis of the Kidney*0015201.scf} Copyright (c) 1993 Tribune Media Services, Inc. Causes, Symptoms, and Treatment of Pyelonephritis ------------------------------------------------------------------------------ QUESTION: I know that you as a physician must have heard about pyelonephritis, but it is a new and disturbing disease for us. I know it has to do with a kidney infection, but little else. What is it, and how do doctors diagnose and treat it? ------------------------------------------------------------------------------ ANSWER: You are correct. It is an infection of the kidney, but the term pyelonephritis refers to the fact that the infecting bacteria strike both at the tissues of the kidney and the renal pelvis. The renal pelvis (from the Greek "pyelos" which means pelvis) is a funnel shaped structure that forms the upper end of the ureter, where it joins the kidney. The ureter, a tube-like organ, carries the urine from the kidney to the bladder. The most common cause of pyelonephritis is a bacterial infection, and the most common bacteria is Escherichia coli, which accounts for about 75 percent of these infections. The bacteria find their way to the kidney by ascending, moving up the ureter from the bladder, where they locate after entering through the urethra (the tube which leads to the bladder from the outside of the body). Certain conditions make it easier for the bacteria to reach the kidney, such as obstructions in the ureter, kidney stones, enlargement of the prostate gland, scars from previous infections of the urinary system, and poor emptying of the bladder. The infection is more common in women, especially during pregnancy, or in older women when they suffer from a "falling uterus". It also often occurs after catheterization of the bladder, when tubes inserted into the bladder provides a route for the bacteria to follow and enter into the system. This is particularly true in patients who suffer from diabetes. Usually the onset of the infection is swift, with chills, fever, pain in the flank, nausea and vomiting. In about 1/3 of the cases, there is urination frequency with pain. Often a tender and enlarged kidney can be felt by the doctor performing the examination. Testing the urine for blood and cells and culturing the specimen for the presence of bacteria can offer the final proof of the diagnosis. Antibiotics provide effective treatment, which should be started as soon as the diagnosis is confirmed. While oral medications are usually adequate, they can be administered by intravenous drip if the infection is severe. ---------------- The material contained here is "FOR INFORMATION ONLY" and should not replace the counsel and advice of your personal physician. Promptly consulting your doctor is the best path to a quick and successful resolution of any medical problem.