$Unique_ID{BRK01946} $Pretitle{} $Title{How do the Elderly and Medications React?} $Subject{Elderly old age aged medication Medications React reaction reactions physical physiological change changes metabolize metabolizes secrete secretes chemical chemicals ingredient ingredients food foods blood system drug drugs Body fat factor factors prescribe prescribed prescription prescriptions senior seniors prevent prevention preventions} $Volume{} $Log{} Copyright (c) 1993 Tribune Media Services, Inc. How do the Elderly and Medications React? ------------------------------------------------------------------------------ QUESTION: I have often heard that many medications work differently in older people than they do in the young. I know there are changes in the body that we can see, but I don't understand how they would affect the medicines. Can you try to explain this to me. I am sure it is complicated but maybe you can make it simple enough for me to understand. ------------------------------------------------------------------------------ ANSWER: As the body grows older, both physical and physiological changes occur. And that changes the way the body is able to metabolize and secrete all the chemical ingredients that pass through our systems, foods as well as medications, for they are all basically chemicals of one nature or another. As the kidney ages, its ability to excrete chemicals diminishes, which means that medications may remain in the blood system for a longer period of time and at higher concentrations than for younger people. The liver is responsible for breaking down many chemicals, and it too slows down, so that drugs remain active longer. Body fat increases in older folks, and so drugs which attach to fat will stay in the body longer. Based upon this, and many other factors, most medications are prescribed in lower or less frequent doses to seniors, to prevent overdosing while maintaining the beneficial effects of properly prescribed medicines. ---------------- The material contained here is "FOR INFORMATION ONLY" and should not replace the counsel and advice of your personal physician. Promptly consulting your doctor is the best path to a quick and successful resolution of any medical problem.