$Unique_ID{BRK01466} $Pretitle{} $Title{Is Podophyllum Dangerous} $Subject{warts genital podophyllum genitourinary podophyllin venereal condylomata acuminata std venereal diseases vd cytotoxic podofilox treatment wart genitals treatments medication medications sexually transmitted disease condyloma acuminatum topical solution} $Volume{R-14,R-15} $Log{ Sexually Transmitted Disease: Venereal Warts*0006403.scf} Copyright (c) 1991-92,1993 Tribune Media Services, Inc. Is Podophyllum Dangerous ------------------------------------------------------------------------------ QUESTION: I have an embarrassing question, that I know you will handle well and perhaps answer in the column. I have warts on my member, and a friend tells me that a doctor can take them off with something called "Podof" or something with a name like that. He warned me it could be dangerous, but I must do something. Do you have any information about this that you can give me? Thank you very much. ------------------------------------------------------------------------------ ANSWER: The name you are looking for is "podophyllum" sometimes spelled "podophyllin". It is a resin made from the dried roots of mandrake or May apple plants. This resin is prepared as a topical solution that is applied directly to venereal warts (Condylomata acuminata), usually with excellent results. Since the solution has a potential toxicity, it must be applied by a physician. The podophyllum is cytotoxic (poison to cells) and since it can be absorbed into the body, it must be used with caution. However it is an excellent treatment for these warts. Marked improvement may be noticed after but a few weeks, but the liquid must be applied frequently and over a long period of time. A newer preparation, called podofilox, is considered safer and still quite effective and can be applied locally by the patient. Though there are local reactions and irritation, they are usually mild. However, even after successful treatment the warts may return. ---------------- The material contained here is "FOR INFORMATION ONLY" and should not replace the counsel and advice of your personal physician. Promptly consulting your doctor is the best path to a quick and successful resolution of any medical problem.