EXPERIMENTAL RESEARCH ON TRADITIONAL CHINESE MEDICINAL HERBS |
Guan Chong Fen,* Wu Xiaoxian**, Lu Yaozeng**, Xu Shuling*. * China Academy of Traditional Chinese Medicine ** Chinese Academy of Medical Sciences.
Objective: Traditional Chinese medicine-ZY-1 Recipe revealed some effects in 104 AIDS patients treated in Tazania. Experimental study was made in animal model monkey, the antivitral, immunomodulatory and pathological effect of ZY-1 Recipe was observed.
Methods: The ZY-1 Recipe was used for experimental treatment on model monkey infected with SIVmac and set up AZT and control group. We carried out the detection of indexes of virology (virus isolation, PCR, SIV and HIV inhibited tests), Immunology (antibody determination IFA, neutralization test; lymphocytic proliferation MTT; CD4, CD3, CD4/CD3 cell count: interferon and reverse transcriptase test) and pathology.
Results: The experimental results showed that as compared to AZT and control group, the ZY-1 Recipe could not only reduce the viral titer 1-2 log of plasma and monocytes in peripheral blood and inhibit the activation of HIV reverse and transcriptase in vitro, but also increse CD4 cells, enhence the ratio of CD4/CD3, promote the proliferation of lymphocytes and induce the r interferon. Particularly in the pathological examination, we discovered that the ZY-1 Recipe could activate and proliferate cells in lymph follicles, geminal centre, paracortical zone and medullary cord of lymph nodes.
Conclusion: The ZY-1 Recipe could inhibit SIV and HIV and increase the immunity of organism. The experimental result in ZY-1 Recipe group was superior to those in AZT and control group. At present, the result of toxicological indicated that te ZY-1 Recipe has no toxic and side effect. It is a safe and effective Chinese herbal medicine in treating AIDS.
Guan Chong Fen, 18 Beixincang Beijing, China 100700
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