The items Mean, Median, Mode, Moment, Quantile, Mean Deviation, Standard Deviation, and Variance on the Statistics submenu take a single argument that can be presented as a list of data or as a matrix. The result of an operation is a number, or, in the case of a matrix, a number for each column.
The items Correlation, Covariance, and Fit Curve to Data on the Statistics submenu take a single argument that must be a matrix. For the curve-fitting commands, the columns must be labeled with variable names. The menu item Random Numbers on the Statistics submenu allows you to get random samples from families of distributions listed in the dialog box that appears when you choose Random Numbers.