What's the difference between layout guides and ruler guides?

Layout guides create a grid that repeats on each page of a publication. You can use layout guides to organize text, pictures, and other objects into columns and rows so that your publication will have a consistent look. Set layout guides by using the Layout Guides command on the Arrange menu. Layout guides are represented by blue and pink dotted lines.

Layout guides are blue and pink. Ruler guides are green.

Add ruler guides to individual pages as you need them. You create ruler guides by holding down SHIFT and then dragging out from the rulers. Ruler guides are represented by green dotted lines.