Document 0787
 DOCN  M9480787
 TI    A p12 gag gene homologue is present in the mouse genome.
 DT    9410
 AU    Casabianca A; Magnani M; Institute of Biological Chemistry G. Fornaini,
       University of; Urbino, Italy.
 SO    Biochem Mol Biol Int. 1994 Mar;32(4):691-6. Unique Identifier : AIDSLINE
       GENBANK/M26005
 AB    A replication-defective virus (BM5d) of approximately 4.9 kb, is
       responsible for a retrovirus induced immunodeficiency syndrome in mice
       (MAIDS) that shares many features with AIDS. BM5d is characterized by
       deletions in env and pol genes, furthermore its gag gene differs
       markedly from gag of other BM5 ecotropic viruses, particularly in its
       p12 sequence. The p12 region of the gag gene has been shown to account
       for the pathogenicity of the BM5d retrovirus. During our studies of BM5d
       integration in mice we found that p12-like sequences are present in the
       mouse genome of uninfected healthy C57BL/6 mice. Cloning and sequencing
       of this p12 gag homologue has revealed a high (63% to 89%) amino acid
       derived sequence identity with other retroviruses and shown that the
       major differences among p12 of pathogenic viral strains compared to
       non-pathogenic ones consist of a four amino acids deletion and a high
       abundance of proline and basic amino acids in their p12 region.
 DE    Amino Acid Sequence  Animal  Base Sequence  Blotting, Southern
       Comparative Study  Defective Viruses/GENETICS  DNA/GENETICS/ISOLATION &
       PURIF  DNA Primers  Gene Products, gag/CHEMISTRY/*GENETICS  *Genes, gag
       Genome  Mice  Mice, Inbred C57BL/*GENETICS  Molecular Sequence Data
       Molecular Weight  Murine Acquired Immunodeficiency Syndrome/MICROBIOLOGY
       Polymerase Chain Reaction/METHODS  Restriction Mapping
       Retroviridae/*GENETICS  Sequence Homology, Amino Acid  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).