Document 0706
 DOCN  M9480706
 TI    Skeletal muscle involvement in tropical spastic
       paraparesis/HTLV-1-associated myelopathy.
 DT    9410
 AU    Gabbai AA; Wiley CA; Oliveira AS; Smith R; Schmidt B; Nobrega JA; Bordin
       JO; Roman GC; Department of Neurology, Escola Paulista de Medicina,
       Brazil.
 SO    Muscle Nerve. 1994 Aug;17(8):923-30. Unique Identifier : AIDSLINE
       MED/94316236
 AB    The frequency of muscle involvement in TSP/HAM is not known, nor is the
       precise role that HTLV-1 and the diverse cytokines play in the genesis
       of HTLV-1-associated diseases. In order to better define the frequency
       and characteristics of the skeletal muscle involvement in TSP/HAM, we
       studied 11 affected patients. EMG was performed in 9 patients and muscle
       biopsy was performed in all 11. Muscle tissue was analyzed using:
       reverse transcriptase PCR for interleukin-1 in 8; PCR for HTLV-1
       proviral DNA in 5; and electron microscopy for viral particles in 3. We
       found pathologic alterations in all 11 patients. Four patients (36%) had
       a neurogenic process, while a primary muscle involvement was observed in
       the rest (64%). Four patients (36%) had polymyositis, and 3 (27%) had a
       noninflammatory myopathy. Muscle weakness in the upper limbs was
       significantly associated with inflammation in the muscle biopsy. EMG was
       abnormal in only 2 of 9 patients. Reverse transcriptase PCR did not
       demonstrate message for interleukin-1 in any sample examined. PCR did
       identify HTLV-1 proviral DNA in the muscle of 3 patients.
       Retroviral-like particles were found, by EM, in only one biopsy. HTLV-1
       may play an important role in the pathogenesis of the frequent
       myopathies associated with HAM/TSP.
 DE    Adult  Base Sequence  Case Report  DNA Primers  DNA, Viral/GENETICS
       Female  Human  HTLV-I/GENETICS  Male  Middle Age  Molecular Sequence
       Data  Muscles/*PATHOLOGY  Paraparesis, Tropical
       Spastic/GENETICS/*PATHOLOGY  Proviruses/GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).