Document 0688
 DOCN  M9480688
 TI    [Treatment with clarithromycin of 173 HIV+ patients with disseminated
       Mycobacterium avium intracellulare infection]
 DT    9410
 AU    Dautzenberg B; Saint-Marc T; Durant J; Reynes J; Meyohas MC; Legrand MF;
       Truffot C; Chauvin JP; Service de Pneumologie, Groupe Hospitalier
       Pitie-Salpetriere,; Paris.
 SO    Rev Mal Respir. 1994;11(3):271-6. Unique Identifier : AIDSLINE
       MED/94316918
 AB    No treatment was established for disseminated M. avium intracellulare
       (MAC) infection, a common disease of end stage of AIDS. An open study
       was conducted to assess in 173 AIDS patients, the activity of
       clarithromycin. Initial bacteriologic eradication from blood was
       observed in 136/147 evaluable patients (93%). Acquired resistance to
       clarithromycin associated with relapse appeared to develop after 2 to 7
       months of drug treatment in 31/136 patients with initial success. Early
       bacteriological relapse was associated with clinical deterioration. Side
       effects of drug treatment were elevated liver enzymes (26%) and impaired
       hearing (4%). Side effects conducted to stop treatment in 14 cases (8%)
       to modified treatment in 8 cases (5%). Our study gave new argues for
       activity of clarithromycin in disseminated MAC infection.
 DE    Adolescence  Adult  Anti-Infective Agents, Fluoroquinolone/THERAPEUTIC
       USE  Antibiotics, Combined  Antitubercular Agents/THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/BLOOD/*DRUG THERAPY/  MICROBIOLOGY
       Child  Clarithromycin/*THERAPEUTIC USE  Clofazimine/THERAPEUTIC USE
       Drug Resistance, Microbial  English Abstract  Female  Hearing
       Disorders/CHEMICALLY INDUCED/EPIDEMIOLOGY  Human  Liver Function Tests
       Male  Middle Age  Minocycline/THERAPEUTIC USE  Mycobacterium
       avium-intracellulare Infection/BLOOD/*DRUG THERAPY/  MICROBIOLOGY
       Recurrence  Treatment Outcome  CLINICAL TRIAL  JOURNAL ARTICLE
       MULTICENTER STUDY

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