AIDS Daily Summary August 16, 1994 The Centers for Disease Control and Prevention (CDC) National AIDS Clearinghouse makes available the following information as a public service only. Providing this information does not constitute endorsement by the CDC, the CDC Clearinghouse, or any other organization. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC Clearinghouse should be cited as the source of this information. Copyright 1994, Information, Inc., Bethesda, MD "Female Condom, Reality, Introduced to U.S. Drugstores" Philadelphia Inquirer (08/16/94) P. A3; Sakson, Steve Wisconsin Pharmacal Co. plans to put its female condom on sale for the first time this month at drugstore counters nationwide. The condom, which is named Reality, comes in a small white box, with pages of instructions and 11 diagrams. Wisconsin Pharmacal plans a $4 million ad campaign emphasizing the condom's role in preventing sexually transmitted diseases as well as pregnancy. The cost is approximately $2.75 each, compared to about a dollar for a male condom. The FDA warns that about 25 percent of Reality's users could get pregnant during a year of use, compared with a 15 to 17 percent rate for male condoms, diaphragms, or sponges. "Counting the Cost of AIDS" Washington Post (Health) (08/16/94) P. 8; Brown, David Measuring the impact of AIDS worldwide is a difficult dilemma for health economists. While estimates of the large financial impact of the epidemic helps coax people into greater action, these huge numbers can obscure some of AIDS' most important effects. For example, while AIDS may not significantly reduce a nation's economic growth rate, it may greatly increase the number of citizens living in poverty. AIDS patients may desire a goal such as comfort during their illness and a pain-free death, a goal which can be overlooked when evaluating medical care in terms of years-of-life-gained-per-amount-spent. Thus, health officials may not realize they can make inexpensive but highly useful investments in things like morphine and clean sheets. Stefano Bertozzi, a World Health Organization economist, speculates that AIDS played in essential role in the Rwandan economy's destruction, "robbing many of the young men in the military [where the infection rate is believed to exceed 20 percent] of their dreams for a long-term future." "D.C. AIDS Program Offers 3 New Drugs" Washington Post (08/16/94) P. B6 The District of Columbia has added diphenoxylate and atropine (Lomatil), dronabinol (Marinol), and megestrol acetate (Megace) to its list of free medications given to AIDS patients without medical insurance. According to Peter Hawley, medical director of the Whitman-Walker Clinic, Lomatil is an appetite stimulant, Marinol is a diarrhea prevention treatment, and Megace is a steroid that helps patients to gain weight. "The Unyielding AIDS Epidemic" New York Times (08/13/94) P. A20 The fight against AIDS will have to be fought for a very long time, warn the editors of the New York Times. The international AIDS conference in Japan has highlighted the dangers of a major breakout of the disease in several Asian nations, including India, Thailand, and China. Meanwhile, scientists report only slow and incremental gains in development of a vaccine and in treatment. The editors compare the battle against AIDS to the fight against cancer, with victory occurring only after a long struggle. "Pay Heed to Women, Say AIDS Activists" Boston Globe (08/15/94) P. 25 The inattention to special problems of AIDS among women and the lack of research on important AIDS-related questions such as mother-child transmission has prompted greater demands for female input in the battle against the deadly disease. The female agenda includes demands for research into the effects on women of the leading AIDS drugs, distribution of accurate information on childbearing by HIV-positive women, and studies of the effects of taking birth-control pills and AIDS medications simultaneously. Karen Lee, a divorced mother from Australia, joined the growing number of activists from around the world trying to force the medical establishment to pay more attention to women, who now account for nearly half of all new infections, compared to just one in three a few years ago. While waiting to discover if she had transmitted HIV to her son, Lee was subject to misinformation on this subject and many others. "Forever on Call" Los Angeles Times (08/14/94) P. E1; Glionna, John Dr. Scott Hitt specializes in AIDS treatment as a partner in the Pacific Oaks Medical Group, one of the country's largest private health-care providers for HIV patients. Hitt treats more than 600 HIV-positive people and another 250 with full-blown AIDS. Hitt is also a gay activist and has recently been mentioned as a candidate for an appointment to the President's AIDS Commission, a policy-making advisory group. On the mounting loss of life, Hitt claims that soon, "the toll from the disease will exceed the number of Americans who died in all of our wars combined." "Infections by Health Worker Spur Tuberculosis Warning" Toronto Globe and Mail (08/12/94) P. A5; Feschuck, Scott Tuberculosis is a growing concern in North America, with AIDS patients being among the most likely to contract it. Health officials in Alberta, Canada, are searching for people who may have come into contact with a health-care worker diagnosed with tuberculosis. The health-care worker, believed to be a doctor, has likely passed the tuberculosis on to dozens of others. TB bacteria often sit dormant for years and become active when a person's immune system is weakened by AIDS. "Firms Start to Focus on AIDS Education" Nikkei Weekly (07/25/94) Vol. 32, No. 1630, P. 21; Kurosaka, Yukinobu As the number of HIV/AIDS patients in Japan totaled 3,317 at the end of April, more and more Japanese businesses discovered that ignoring the disease will not make it disappear. About two years ago, a movement seeking to curb the spread of AIDS began in Japanese business circles. Companies gave employees AIDS-prevention guidelines and attended seminars. The surge of information appeared to create the perception that the Japanese had done enough, and many companies lost their aggressiveness in the battle against the disease. Some groups, however, today continue to introduce new AIDS-prevention measures. For example, teachers in the greater Osaka region recently held a seminar on AIDS-related topics. And the Japan International Cooperation Agency is now providing emergency medical kits to employees who are given overseas assignments. The packs include sterilized syringes and instruments. Much more must be done, however, to fight AIDS and install life-saving measures. "HIV And Anal Cancer; Anal Pap Smears, Early Treatment, Recommended for High-Risk Men & Women" AIDS Treatment News (07/22/94) P. 2; Smith, Denny Joel Palefsky, M.D. and his staff at the University of California has been surveying possible increases in precancerous changes in anal tissue that might occur in people who have both the human papilloma virus(HPV), which causes genital and anal warts, and HIV. His observations, boosted by other similar studies, start from the idea that HPV may cause some abnormal anal cells, called dysplasia; then those cells may later turn into actual tumors, or neoplasia. Some researchers think that co-infection with HIV might increase the rate of dysplasia. Dr. Palefksy's staff looked at the cancer registry statistics for San Francisco, and saw the rate of reported anal cancer was higher in communities that had a greater number of people who are HIV-positive. Now, there are indications that HPV/HIV co-infection is strongly linked with neoplasia in the cervix(cervical intraepithelial neoplasia, or CIN), and in the anus(anal intraepithelial neoplasia, or AIN). In one of Palefsky's AIN studies of men , he discovered that 11 percent of the HIV-positive group had AIN, as compared to 2 percent of the control group. AIN can be detected using Pap smears of anal cells. Most AIDS care providers don't furnish this test, but data from studies might change this. Dr. Palefsky recommends annual AIN screens for all HIV-positive people with CD4 counts below 500, women with a history of virulent CIN, and all men who have a history of being the receptive partner in anal sex.